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Search Results for " dna interstrand cross-links "

7

Compounds

Cat No. Product Name Synonyms Targets
T0974 Novobiocin Sodium Albamycinsodium,Cathomycin,Albamycin Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim...
T2410 Nedaplatin NSC 375101D DNA/RNA Synthesis
Nedaplatin (NSC-375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand...
T4558 Trioxsalen Trimethylpsoralen,Trioxysalen,Trisoralen DNA Alkylator/Crosslinker , DHFR
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh...
T34628 SG3199 SG 3199,SG-3199
SG3199 is a PBD dimer which binds in the minor groove of DNA, and forms covalent DNA interstrand cross-links in naked linear plasmid DNA. SG3199 is potently cytotoxic against a panel of human solid tumour and haematologi...
T72817 Colibactin 742
Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads to G2/M arrest.
T68675 Porfiromycin
Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radic...
T68942 Caricotamide
Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the pro...
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